Hyperandrogenism Does Not Influence Metabolic Parameters in Adolescent Girls with PCOS

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Hyperandrogenism Does Not Influence Metabolic Parameters in Adolescent Girls with PCOS

Background. Underlying insulin resistance and/or obesity has clearly been implicated in the development of metabolic syndrome in adolescents and young adults with polycystic ovarian syndrome (PCOS). It is not clear however what role hyperandrogenism has on the development of metabolic syndrome or its role on those metabolic parameters associated with metabolic syndrome. Methods. We studied 107 ...

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Adrenal hyperandrogenism does not deteriorate insulin resistance and lipid profile in women with PCOS

OBJECTIVE The aim of this study was to investigate the impact of adrenal hyperandrogenism on insulin resistance and lipid profile in women with polycystic ovary syndrome (PCOS). PATIENTS AND METHODS We studied 372 women with PCOS according to the NIH criteria. 232 age- and BMI-matched women served as controls in order to define adrenal hyperandrogenism (DHEA-S >95th percentile). Then, patient...

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Early metabolic abnormalities in adolescent girls with polycystic ovarian syndrome.

OBJECTIVE To investigate insulin sensitivity and secretion in young adolescent girls with childhood onset polycystic ovarian syndrome (PCOS) and to identify the early metabolic derangement(s). STUDY DESIGN Twelve obese girls with PCOS (age 12.0+/-0.7 years) were compared with 10 obese nonhyperandrogenic girls (control group). The groups were matched for age, percent body fat, and abdominal fa...

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Natural molecules for the therapy of hyperandrogenism and metabolic disorders in PCOS.

OBJECTIVE Polycystic ovary syndrome (PCOS) is the most common endocrinopathy of women of reproductive age and a complex endocrine condition, due to its heterogeneity and uncertainty about its etiology. However, PCOS is also associated with other metabolic abnormalities such as insulin resistance, impaired glucose tolerance, and diabetes. There are few medications that are approved for the most ...

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Development of obesity and polycystic ovary syndrome in adolescents.

Obesity in adolescents is prevalent worldwide. Polycystic ovary syndrome (PCOS) is often associated with obesity in women, and it has serious metabolic and reproductive health implications. Although PCOS does not become clinically visible until early adolescence, its origins are likely much earlier. Therefore, we reviewed the recent literature regarding the mechanisms linking the development of...

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ژورنال

عنوان ژورنال: International Journal of Endocrinology

سال: 2012

ISSN: 1687-8337,1687-8345

DOI: 10.1155/2012/434830